A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition.

doi:10.1101/gad.445108

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Article

A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition.

Genes & development - 1 Apr 2008

Cuvier Olivier, Stanojcic Slavica, Lemaitre Jean-Marc, Mechali Marcel

Abstract excerpt

Topoisomerase II (topo II) is required for chromosome segregation and for reprogramming replicons. Here, we show that topo II couples DNA replication termination with the clearing of replication complexes for resetting replicons at mitosis. Topo II inhibition impairs completion of DNA replication, accounting for replication protein A (RPA) stabilization onto ssDNA. Topo II inhibition does not affect the...

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PMID: 18381889
DOI: 10.1101/gad.445108
PMCID: PMC2279196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.