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Article

Recovery of arrested replication forks by homologous recombination is error-prone.

PLoS genetics - 1 Jan 2012

Iraqui Ismail, Chekkal Yasmina, Jmari Nada, Pietrobon Violena, Fréon Karine, Costes Audrey, Lambert Sarah A E

Abstract excerpt

Homologous recombination is a universal mechanism that allows repair of DNA and provides support for DNA replication. Homologous recombination is therefore a major pathway that suppresses non-homology-mediated genome instability. Here, we report that recovery of impeded replication forks by homologous recombination is error-prone. Using a fork-arrest-based assay in fission yeast, we demonstrate that a single...

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PMID: 23093942
DOI: 10.1371/journal.pgen.1002976
PMCID: PMC3475662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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