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Article

FANCM: fork pause, rewind and play.

The EMBO journal - 17 Feb 2010

Collis Spencer J, Boulton Simon J

Abstract excerpt

DNA lesions or genomic regions that are difficult to traverse frequently hinder or block DNA replication. In response to replication fork stalling, the cell activates the replication stress response pathway, which acts to protect the fork from collapse, promotes the repair or bypass of the blocka...

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Source

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Identifiers

PMID: 20160754
DOI: 10.1038/emboj.2009.415
PMCID: PMC2829172

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20160754-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FANCM: fork pause, rewind and play.PMID 20160754Read ↗

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.Semantic proximity Read ↗

The FANCM family of DNA helicases/translocasesSemantic proximity Read ↗

Advances in understanding DNA processing and protection at stalled replication forksSemantic proximity Read ↗

Impediments to replication fork movement: stabilisation, reactivation and genome instability.Semantic proximity Read ↗

FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes.Semantic proximity Read ↗

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during StressSemantic proximity Read ↗

FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recoverySemantic proximity Read ↗

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.Semantic proximity Read ↗

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.Semantic proximity Read ↗

Fork pausing complex engages topoisomerases at the replisome.Semantic proximity Read ↗

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation HotspotsSemantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

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