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Article

Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro

3 Aug 2015

Abstract excerpt

BACKGROUND: Autophagy is a conserved cellular self-digestion mechanism that can either suppress or promote cancer in a context-dependent manner. In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis and that Beclin-1 is a haploinsufficient tumor suppressor. Nonetheless, autophagy is known to be readily inducible in...

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PMID: 26239434
DOI: 10.1186/s13048-015-0182-y

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