Article

Loss of ULK1 impairs autophagy activation, spheroid viability, and tumor progression in epithelial ovarian cancer

2023-10-03

Abstract excerpt

<h4>Introduction: </h4> Epithelial ovarian cancer (EOC) remains a leading cause of gynecological cancer-related deaths due its late diagnosis and the absence of effective treatments for chemo-resistant disease. EOC metastasizes through peritoneal dissemination, often forming multicellular spheroids, in which autophagy—a cell survival mechanism—is induced, requiring ULK1 (Unc-51-like kinase 1) activity. Our study a...

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Literature Corpus work: 94ae45ac-6c42-5a01-b062-ed9a90c3a4ff
DOI: 10.21203/rs.3.rs-3352490/v1

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