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The Biological Role and Clinical Significance of BECLIN-1 in Cancer

2025-07-29

Abstract excerpt

BECLIN-1 is a multidomain protein that through dynamic interaction with a variety of partners controls autophagy and apoptosis, two processes dysregulated in cancer cells, thus playing a crucial role in cell destiny. Mutations of BECN1 gene have not been described, yet its monoallelic deletion leads to insufficient autophagy with an impact on spontaneous cancer development, which identifies it as a haploinsufficie...

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Literature Corpus work
9e821188-270b-5ed1-837b-a443dc09aef6
DOI
10.20944/preprints202507.2396.v1
Open publication

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The Biological Role and Clinical Significance of BECLIN-1 in CancerDOI 10.20944/preprints202507.2396.v1
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