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Article

Somatic mutations of BECN1, an autophagy-related gene, in human cancers.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jun 2007

Lee Jong Woo, Jeong Eun Goo, Lee Sung Hak, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

Evasion of programmed cell death (PCD) is one of the hallmarks of human cancers. It is well known that not only apoptosis, but also autophagy, acts as an action mechanism of PCD. BECN1 protein is a key regulator of autophagic PCD. The BECN1 gene that encodes BECN1 protein acts as a haploinsufficient tumor-suppressor gene. However, to date, data on BECN1 mutation in human cancer tissues are lacking. To explore the...

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PMID: 17550384
DOI: 10.1111/j.1600-0463.2007.apm_640.x

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BECN1

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