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Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

10 Jan 2020

Abstract excerpt

Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is complicated due to its genomic proximity to BRCA1 on both human (chromosome 17) and murine (chromosome 11) genomes. In human breast and ovarian cancers, the monoallelic...

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PMID: 31923184
DOI: 10.1371/journal.pgen.1008558

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