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Article

Mutational Landscape of the Essential Autophagy Gene <i>BECN1</i> in Human Cancers

29 Jan 2014

Abstract excerpt

UNLABELLED: Evidence suggests that the catabolic process of macroautophagy (autophagy hereafter) can either suppress or promote cancer. The essential autophagy gene ATG6/BECN1 encoding the Beclin1 protein has been implicated as a haploinsufficient tumor suppressor in breast, ovarian, and prostate cancers. The proximity of BECN1 to the known breast and ovarian tumor suppressor breast cancer 1, early onset, BRCA1,...

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PMID: 24478461
DOI: 10.1158/1541-7786.mcr-13-0614

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