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Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

16 Jan 2015

Abstract excerpt

Both BRCA1 and Beclin 1 ( BECN1 ) are tumor suppressor genes, which are in close proximity on the human chromosome 17q21 breast cancer tumor susceptibility locus and are often concurrently deleted. However, their importance in sporadic human breast cancer is not known. To interrogate the effects of BECN1 and BRCA1 in breast cancer, we studied their mRNA expression patterns in breast cancer patients from two large...

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PMID: 25825707
DOI: 10.1016/j.ebiom.2015.01.008

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