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Isolation, Characterization, and Autophagy Function of BECN1-Splicing Isoforms in Cancer Cells

2 Aug 2022

Abstract excerpt

Alternative splicing allows the synthesis of different protein variants starting from a single gene. Human Beclin 1 (BECN1) is a key autophagy regulator that acts as haploinsufficient tumor suppressor since its decreased expression correlates with tumorigenesis and poor prognosis in cancer patients. Recent studies show that BECN1 mRNA undergoes alternative splicing. Here, we report on the isolation and molecular...

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PMID: 36008963
DOI: 10.3390/biom12081069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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