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Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

25 Jan 2021

Abstract excerpt

Significance Beclin 1, an essential autophagy protein, is important for tumor suppression in mice, as well as in human breast and ovarian cancers. However, it is not well understood how Beclin 1 acts as a tumor suppressor. By performing a genetic screen to identify genes whose loss blocks the ability of Beclin 1 to inhibit the growth of breast cancer cells and follow-up biological analyses, we have identified a...

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PMID: 33495338
DOI: 10.1073/pnas.2020478118

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