Article

AMPK-independent LKB1 activity is required for efficient epithelial ovarian cancer metastasis

2019-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Epithelial ovarian cancer (EOC) spreads by direct dissemination of malignant cells and multicellular clusters, known as spheroids, into the peritoneum followed by implantation and growth on abdominal surfaces. Using a spheroid model system of EOC metastasis, we discovered that Liver kinase B1 (LKB1), encoded by the STK11 gene, and its canonical substrate AMP-activated protein kinase (AMPK) are...

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Literature Corpus work: bea7e61d-9e62-582f-83a4-2dc1aee2b55d
DOI: 10.1101/591073

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