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Article

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Nature genetics - 1 Sept 2015

Lavallée Vincent-Philippe, Baccelli Irène, Krosl Jana, Wilhelm Brian, Barabé Frédéric, Gendron Patrick, Boucher Geneviève, Lemieux Sébastien, Marinier Anne, Meloche Sylvain, Hébert Josée, Sauvageau Guy

Abstract excerpt

Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we identified to our knowledge the first unifying genetic network common to the two subgroups of KMT2A (MLL)-rearranged leukemia, namely having MLL fusions or partial tandem duplications. Within this network, we experimentally confirmed upregulation of the gene with the most subtype-specific increase in expression, LOC100289656,...

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Share to Gene Expression Regulation, Leukemic
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Myeloid-Lymphoid Leukemia Protein

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Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 26237430
DOI: 10.1038/ng.3371

Genes

ENAH
SPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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