Multi-omics-guided dynamic precision medicine in leukemia: An AML-centered framework integrating genotype, cellular state, bone marrow pathology, and the immune ecosystem.

Abstract excerpt

Leukemia comprises a group of hematologic malignancies characterized by pronounced molecular heterogeneity, cellular-state plasticity, and highly variable clinical outcomes. With the rapid development of high-throughput sequencing, single-cell and spatial omics, molecular measurable residual disease monitoring, and immune-engineering technologies, the diagnostic and therapeutic paradigm of leukemia is shifting...

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