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Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML

9 Jan 2025

Abstract excerpt

Acute Myeloid Leukemia (AML) with KMT2A rearrangements (KMT2Ar), found on chromosome 11q23, is often called KMT2A-rearranged AML (KMT2Ar-AML). This variant is highly aggressive, characterized by rapid disease progression and poor outcomes. Growing knowledge of epigenetic changes, especially lactylation, has opened new avenues for investigation and management of this subtype. Lactylation plays a significant role...

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PMID: 39789150
DOI: 10.1038/s41598-025-86136-2

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