Article
Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.
Nature cancer - 1 Jun 2026
Chu Shih-Chun A, Hsiao Yi, Wang Chenwei, Kyle Jennifer E, Jain Raghav, Deng Yamei, Gritsenko Marina A, Henry Leanne E, Lei Jonathan T, Dou Yongchao, Tercan Bahar, Shi Zhiao, Gondal Mahnoor N, Tsai Chia-Feng, Elizarraras John M, Chu Rosalie K, Yu Fengchao, Joshi Sunil K, Jing Xiaojun, Polasky Daniel A, Weitz Karl K, Li Ginny Xiaohe, Paurus Vanessa L, Clendinen Chaevien S, Schepmoes Athena A, Lalli Priscila M, Eder Josie G, Flores Javier E, Stratton Kelly G, Pino James C, Posso Camilo, Petyuk Vladislav A, Sagendorf Tyler J, Xu Yuanwei, Ibrahim Omar M, Moore Ronald J, Zhao Rui, Chen Jin, Monroe Matthew E, Thiagarajan Mathangi, Hostetter Galen, Newton Chelsea, An Eunkyung, Robles Ana I, Zhang Xu, Edwards Nathan J, Lu Yin, Zhang Hui, Abdelhakim Haitham, Piehowski Paul D, Mesri Mehdi, Smith Richard D, Kumar-Sinha Chandan, Tognon Cristina E, Dunlap Jennifer, Traer Elie, Ding Li, Tyner Jeffrey W, Chinnaiyan Arul M, Omenn Gilbert S, Rodland Karin D, Dhanasekaran Saravana M, Gosline Sara J C, Nesvizhiskii Alexey I, Zhang Bing, Liu Tao, Cieslik Marcin P
Abstract excerpt
Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous hematological malignancy. Here, to better define this clinically taxing and translationally challenging malignancy, we applied a multiomics approach, consisting of 13 modalities to analyze 173 treatment-naive individuals with AML. By integrating these 'omes', we identified distinct AML subtypes, genotype-phenotype associations,...
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