Article
Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing.
Leukemia - 1 Jan 2021
Arindrarto Wibowo, Borràs Daniel M, de Groen Ruben A L, van den Berg Redmar R, Locher Irene J, van Diessen Saskia A M E, van der Holst Rosalie, van der Meijden Edith D, Honders M Willy, de Leeuw Rick H, Verlaat Wina, Jedema Inge, Kroes Wilma G M, Knijnenburg Jeroen, van Wezel Tom, Vermaat Joost S P, Valk Peter J M, Janssen Bart, de Knijff Peter, van Bergen Cornelis A M, van den Akker Erik B, Hoen Peter A C 't, Kiełbasa Szymon M, Laros Jeroen F J, Griffioen Marieke, Veelken Hendrik
Abstract excerpt
Acute myeloid leukemia (AML) is caused by genetic aberrations that also govern the prognosis of patients and guide risk-adapted and targeted therapy. Genetic aberrations in AML are structurally diverse and currently detected by different diagnostic assays. This study sought to establish whole transcriptome RNA sequencing as single, comprehensive, and flexible platform for AML diagnostics. We developed HAMLET...
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