Lactylation Modulation Identifies Key Biomarkers and Therapeutic Targets in KMT2A- Rearranged AML

Abstract excerpt

<title>Abstract</title> <p>Acute Myeloid Leukemia (AML) with KMT2A rearrangements (KMT2Ar), found on chromosome 11q23, is often called KMT2A-rearranged AML (KMT2Ar-AML). This variant is highly aggressive, characterized by rapid disease progression and poor outcomes. Growing knowledge of epigenetic changes, especially lactylation, has opened new avenues for investigation and management of this subtype. Lactylation...

Topics

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• Acute Myeloid Leukemia Research
• Epigenetics and DNA Methylation
• Gene Expression Regulation, Leukemic
• Histone Deacetylase Inhibitors Research
• Histone-Lysine N-Methyltransferase
• Mice, Inbred NOD
• Myeloid-Lymphoid Leukemia Protein
• Translocation, Genetic

Identifiers and source

Literature Corpus work

e284e547-8ece-58cb-912f-6a264ca41fd8

DOI

10.21203/rs.3.rs-5218493/v1