Article
A 3'-UTR Polymorphism in Soluble Epoxide Hydrolase Gene Is Associated with Acute Rejection in Renal Transplant Recipients.
PloS one - 1 Jan 2015
Gervasini Guillermo, García-Cerrada Montserrat, Coto Eliecer, Vergara Esther, García-Pino Guadalupe, Alvarado Raul, Fernández-Cavada Maria Jesús, Suárez-Álvarez Beatriz, Barroso Sergio, Doblaré Emilio, Díaz-Corte Carmen, López-Larrea Carlos, Cubero Juan Jose
Abstract excerpt
BACKGROUND AND PURPOSE: Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that play a protective role against damaging processes that may occur after re-oxygenation of the graft. We aimed to investigate whether the presence of functional polymorphisms in the gene encoding soluble epoxy hydrolase (EPHX2), which metabolizes EETs to less active compounds, may play a role in the outcome of renal...
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