Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors.

Journal of clinical pharmacology - 1 Apr 2013

Gervasini Guillermo, Garcia Montserrat, Macias Rosa María, Benitez Julio, Caravaca Francisco, Cubero Juan Jose

Abstract excerpt

Epoxieicosatrienoic acids (EETs) play a protective role against damaging processes in the kidney. We have assessed the effect of polymorphisms in EETs-producing enzymes (CYP2C8 and CYP2J2) and other proteins involved in calcineurin inhibitors (CNIs) disposition (CYP3A4, CYP3A5, and ABCB1) on graft function and clinical outcome in 166 renal transplant recipients treated with CNIs. Both CYP2C8*3 and donor age...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcineurin Inhibitors

Share to Cyclosporine

Share to Cytochrome P-450 CYP2C8

Share to Graft Rejection

Share to Tissue Donors

Share to Transplantation, Homologous

Source

Identifiers

PMID: 23426640
DOI: 10.1002/jcph.15

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors.PMID 23426640Read ↗

Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.Semantic proximity Read ↗

Pharmacogenetics and drug-induced nephrotoxicity in renal transplant recipientsSemantic proximity Read ↗

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis.Semantic proximity Read ↗

Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation.Semantic proximity Read ↗

CYP3A genotypes of donors but not those of the patients increase the risk of acute rejection in renal transplant recipients on calcineurin inhibitors: a pilot study.Semantic proximity Read ↗

Donor ABCB1 variant associates with increased risk for kidney allograft failure.Semantic proximity Read ↗

Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up.Semantic proximity Read ↗

The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.Semantic proximity Read ↗

The pharmacogenetics of calcineurin inhibitor-related nephrotoxicity.Semantic proximity Read ↗

Polymorphisms in CYP-mediated arachidonic acid routes affect the outcome of renal transplantation.Semantic proximity Read ↗

Association of CYP3A variants with kidney transplant outcomes.Semantic proximity Read ↗

Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.