Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential roles of methionine and <i>S</i> -adenosylmethionine in the autarkic lifestyle of <i>Mycobacterium tuberculosis</i>

28 Jul 2015

Abstract excerpt

Multidrug resistance, strong side effects, and compliance problems in TB chemotherapy mandate new ways to kill Mycobacterium tuberculosis (Mtb). Here we show that deletion of the gene encoding homoserine transacetylase (metA) inactivates methionine and S-adenosylmethionine (SAM) biosynthesis in Mtb and renders this pathogen exquisitely sensitive to killing in immunocompetent or immunocompromised mice, leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mycobacterium research and diagnosis
Share to Pneumocystis jirovecii pneumonia detection and treatment
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26221021
DOI: 10.1073/pnas.1513033112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential roles of methionine and <i>S</i> -adenosylmethionine in the autarkic lifestyle of <i>Mycobacterium tuberculosis</i>PMID 26221021Read ↗

Identifying a novel mechanism of L-leucine uptake in <i>Mycobacterium tuberculosis</i> using a chemical genomic approachSemantic proximity Read ↗

Dependency on the host vitamin B12 has shaped the Mycobacterium tuberculosis Complex evolutionSemantic proximity Read ↗

Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

<i>De novo</i> cobalamin biosynthesis, transport and assimilation and cobalamin-mediated regulation of methionine biosynthesis in <i>Mycobacterium smegmatis</i>Semantic proximity Read ↗

KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against <i>Mycobacterium Tuberculosis</i>Semantic proximity Read ↗

Systems analysis reveals alternate metabolic states adopted by <i>Mycobacterium tuberculosis</i> across speciesSemantic proximity Read ↗

Fatty acid oxidation impairs macrophage effector functions that control <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

REBASTINIB, OLVEREMBATINIB, AND NAS-181 INHIBIT <i>MYCOBACTERIUM ABSCESSUS</i> BY DISRUPTING MYCOTHIOL HOMEOSTASISSemantic proximity Read ↗

Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolutionSemantic proximity Read ↗

The <i>Mycobacterium tuberculosis</i> long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infectionSemantic proximity Read ↗

MtrA regulation of essential peptidoglycan cleavage in <i>Mycobacterium tuberculosis</i> during infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.