Article

Fatty acid oxidation impairs macrophage effector functions that control <i>Mycobacterium tuberculosis</i>

2019-10-10

Abstract excerpt

<h4>SUMMARY</h4> Macrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. How these metabolic shifts influence the outcome of infection by intracellular pathogens remains incompletely understood. M. tuberculosis (Mtb) modulates host metabolic pathways and utilizes host nutrients, including cholesterol and fatty acids, to survive within macrophages. We found that intrace...

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Literature Corpus work: be197968-b294-5f96-a652-17944822ee47
DOI: 10.1101/799619

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