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Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against <i>Mycobacterium Tuberculosis</i>

2025-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Conditionally essential pathways - such as the biotin biosynthesis - represent promising targets for new antibiotics. However, the chemical interrogation of the biotin pathway with an orally effective lead remains elusive, and the preclinical development of biotin inhibitors for mycobacterial infections in vivo is challenging due to the unusually high concentration of biotin in standard mouse mo...

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Literature Corpus work
577388c8-6e89-5c2e-8739-5f55e8b286b2
DOI
10.1101/2025.09.24.678246
Open publication

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Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against <i>Mycobacterium Tuberculosis</i>DOI 10.1101/2025.09.24.678246
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