Article

Dependency on the host vitamin B12 has shaped the Mycobacterium tuberculosis Complex evolution

2023-03-01

Abstract excerpt

<title>Abstract</title> <p>Human and animal tuberculosis is caused by the <italic>Mycobacterium tuberculosis</italic> Complex, which have evolved a genomic decay of cobalamin (vitamin B12) biosynthetic genes. Accordingly, and in sharp contrast to environmental, opportunistic and ancestor mycobacteria; we demonstrate that <italic>M. tuberculosis</italic> (<italic>Mtb</italic>), <italic>M. africanum</italic>, and a...

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Literature Corpus work: 12cfd7c0-abab-587e-a540-0ac19bd87fb8
DOI: 10.21203/rs.3.rs-2487911/v1

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