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Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

9 Mar 2024

Abstract excerpt

Human and animal tuberculosis is caused by the Mycobacterium tuberculosis Complex (MTBC), which has evolved a genomic decay of cobalamin (vitamin B12) biosynthetic genes. Accordingly, and in sharp contrast to environmental, opportunistic and ancestor mycobacteria; we demonstrate that M. tuberculosis (Mtb), M. africanum, and animal-adapted lineages, lack endogenous production of cobalamin, yet they retain the...

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PMID: 38461302
DOI: 10.1038/s41467-024-46449-8

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