Identification of a tendon phenotype in GDF6 deficient mice.

Abstract excerpt

Increasing evidence suggests that the growth/differentiation factors, GDFs 5, 6, and 7 in particular, may play a role in tendon and ligament biology. Mice with genetic mutations in Gdf5 have altered tendon composition and mechanical behavior, whereas animals with functional null mutations in Gdf7 have a more subtle tendon phenotype. The present study demonstrates for the first time that a null mutation in Gdf6 is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mice
• Share to Mice, Inbred C57BL
• Share to Mice, Knockout