Article
A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis.
Developmental biology - 1 Apr 2008
Koyama Eiki, Shibukawa Yoshihiro, Nagayama Motohiko, Sugito Hiroki, Young Blanche, Yuasa Takahito, Okabe Takahiro, Ochiai Takanaga, Kamiya Nobuhiko, Rountree Ryan B, Kingsley David M, Iwamoto Masahiro, Enomoto-Iwamoto Motomi, Pacifici Maurizio
Abstract excerpt
The origin, roles and fate of progenitor cells forming synovial joints during limb skeletogenesis remain largely unclear. Here we produced prenatal and postnatal genetic cell fate-maps by mating ROSA-LacZ-reporter mice with mice expressing Cre-recombinase at prospective joint sites under the control of Gdf5 regulatory sequences (Gdf5-Cre). Reporter-expressing cells initially constituted the interzone, a compact...
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