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Article

Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2015

Ohta Yoichi, Okabe Takahiro, Larmour Colleen, Di Rocco Agnese, Maijenburg Marijke W, Phillips Amanda, Speck Nancy A, Wakitani Shigeyuki, Nakamura Takashi, Yamada Yoshihiko, Enomoto-Iwamoto Motomi, Pacifici Maurizio, Iwamoto Masahiro

Abstract excerpt

OBJECTIVE: To determine whether and how the transcription factor Erg participates in the genesis, establishment, and maintenance of articular cartilage. METHODS: Floxed Erg mice were mated with Gdf5-Cre mice to generate conditional mutants lacking Erg in their joints. Joints of mutant and control mice were subjected to morphologic and molecular characterization and also to experimental surgically induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26097038
DOI: 10.1002/art.39243
PMCID: PMC5568074

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