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Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity

1 Jan 2015

Abstract excerpt

For more than 40 years L-asparaginases are used in combined therapy of acute lymphoblastic leukemia in children and the range of tumors sensitive to these enzymes constantly extends. This review summarizes results of studies aimed at creation of new systems for heterological expression of bacterial L-asparaginases as Erwinia carotovora (EwA), Helicobacter pylori (HpA), Yersinia pseudotuberculosis (YpA) and...

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PMID: 26215408
DOI: 10.18097/pbmc20156103312

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