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Article

Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.

15 Feb 1993

Abstract excerpt

The crystal structure of Escherichia coli asparaginase II (EC 3.5.1.1), a drug (Elspar) used for the treatment of acute lymphoblastic leukemia, has been determined at 2.3 A resolution by using data from a single heavy atom derivative in combination with molecular replacement. The atomic model was refined to an R factor of 0.143. This enzyme, active as a homotetramer with 222 symmetry, belongs to the class of...

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PMID: 8434007
DOI: 10.1073/pnas.90.4.1474

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