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Article

A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination.

PloS one - 1 Jan 2015

Rubtsova Svetlana N, Zhitnyak Irina Y, Gloushankova Natalya A

Abstract excerpt

Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells. Live-cell imaging of neoplastic cells stably expressing EGFP and of normal epithelial cells stably expressing mKate2 showed that transformed cells retaining expression of E-cadherin were able to migrate over the IAR-2 epithelial...

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Identifiers

PMID: 26207916
DOI: 10.1371/journal.pone.0133578
PMCID: PMC4514802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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