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Article

Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells.

Biochemical and biophysical research communications - 5 Mar 2021

Jebri Imen, Tsujita Kazuya, Fujita Yasuyuki, Itoh Toshiki

Abstract excerpt

Oncogenic transformation enables cells to behave differently from their neighboring normal cells. Both cancer and normal cells recognize each other, often promoting the extrusion of the former from the epithelial cell layer. Here, we show that RasV12-transformed normal rat kidney 52E (NRK-52E) cells are extruded towards the basal side of the surrounding normal cells, which is concomitant with enhanced motility....

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PMID: 33503542
DOI: 10.1016/j.bbrc.2021.01.031

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