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Article

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.

Science (New York, N.Y.) - 21 Nov 1997

Hordijk P L, ten Klooster J P, van der Kammen R A, Michiels F, Oomen L C, Collard J G

Abstract excerpt

Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In epithelial Madin-Darby canine kidney (MDCK) cells, Tiam1 localized to adherens junctions. Ectopic expression of Tiam1 or RacV12 inhibited hepatocyte growth factor-induced scattering by increasing E-cadherin-mediated cell-cell adhesion accompanied by actin...

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Source

Identifiers

PMID: 9367959
DOI: 10.1126/science.278.5342.1464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.PMID 9367959Read ↗

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.Semantic proximity Read ↗

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signalingSemantic proximity Read ↗

The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.Semantic proximity Read ↗

The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration.Semantic proximity Read ↗

RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma.Semantic proximity Read ↗

EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancerSemantic proximity Read ↗

Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells.Semantic proximity Read ↗

Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration.Semantic proximity Read ↗

Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability.Semantic proximity Read ↗

Tiam1 mutations in human renal-cell carcinomas.Semantic proximity Read ↗

Rho GTPases modulate malignant transformation of tumor cells.Semantic proximity Read ↗

p120 Catenin is required for growth factor-dependent cell motility and scattering in epithelial cells.Semantic proximity Read ↗

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