Article
Intercellular junctions: downstream and upstream of Ras?
Seminars in cell & developmental biology - 1 Aug 2000
Mercer J A
Abstract excerpt
Most human tumors are of epithelial origin, and these tumors gradually lose their epithelial character in a process termed the epithelial-mesenchymal transition. Approximately 40% of human tumors have activating mutations in one of the three RAS genes. Given these statistics, it is critically important to understand the role of Ras signaling in the epithelial-mesenchymal transition. This review considers the...
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