Article
Effect of Functionally Significant Deiodinase Single Nucleotide Polymorphisms on Drinking Behavior in Alcohol Dependence: An Exploratory Investigation.
Alcoholism, clinical and experimental research - 1 Sept 2015
Lee Mary R, Schwandt Melanie L, Bollinger Jared W, Dias Alexandra A, Oot Emily N, Goldman David, Hodgkinson Colin A, Leggio Lorenzo
Abstract excerpt
BACKGROUND: Abnormalities of the hypothalamic-pituitary-thyroid (HPT) axis have been reported in alcoholism; however, there is no definitive agreement on the specific thyroid abnormalities and their underlying mechanisms in alcohol dependence. The biological activity of thyroid hormones or the availability of T3 is regulated by the three deiodinase enzymes: D1, D2, and D3. In the context of alcohol use,...
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