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Article

Characterization of functional polymorphisms and glucocorticoid-responsive elements in the promoter of TDO2, a candidate gene for ethanol-induced behavioural disorders.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Soichot Marion, Vaast Arnaud, Vignau Jean, Guillemin Gilles J, Lhermitte Michel, Broly Franck, Allorge Delphine

Abstract excerpt

AIMS: In response to acute ethanol consumption, tryptophan 2,3-dioxygenase (TDO) induces the kynurenine pathway (KP) through a glucocorticoid-mediated mechanism, which could lead to a dramatic accumulation of neurotoxic metabolites in association with serotonin depletion. As a result, interindivi...

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Source

Identifiers

PMID: 23558111
DOI: 10.1093/alcalc/agt028

Genes

TDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23558111-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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