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Determination of frequency of Type 2 deiodinase Thr92Ala polymorphism (rs225014) in 131I-treated differentiated thyroid cancer patients undertaking L-Thyroxine (L-T4) suppression therapy.

2023-06-29

Abstract excerpt

<h4>Purpose: </h4> Type 2 deiodinase (DIO2) enzyme plays vital role in peripheral T4 to T3 conversion and regulation of TSH secretion. rs225014 is a common single nucleotide polymorphism (SNP) which is known to reduce DIO2 activity. The differentiated thyroid cancer patients (DTC) are given L-T4 therapy after total thyroidectomy and 131 I-treatment to suppress TSH levels. This study was undertaken to determine the...

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Literature Corpus work
c75b31b0-be06-583b-92b8-5436292fdddb
DOI
10.21203/rs.3.rs-3070668/v1
Open publication

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