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Article

Thyroid Hormone Dynamics and DIO2 Variants in Schizophrenia: Exploring Genetic Links to Neuroendocrine Imbalance.

Journal of cellular and molecular medicine - 1 Jul 2025

Akan Gokce, Adolf Ismael Chatita, Colak Adil, Acar Seda, Oncu Fatih, Yesilbursa Dogan, Turkcan Solmaz, Atalar Fatmahan, Gazioglu Sema Bilgic

Abstract excerpt

Thyroid hormone modulates multiple neurotransmitter systems, including dopaminergic, serotonergic, glutamatergic and GABAergic pathways, which are implicated in schizophrenia (SCH) pathophysiology. The Type II deiodinase (DIO2) enzyme plays a critical role in thyroid metabolism, converting thyroxine (T4) into the biologically active triiodothyronine (T3). This study aimed to investigate the potential association...

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Identifiers

PMID: 40586856
DOI: 10.1111/jcmm.70694
PMCID: PMC12207988

Genes

DIO2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Thyroid Hormone Dynamics and DIO2 Variants in Schizophrenia: Exploring Genetic Links to Neuroendocrine Imbalance.PMID 40586856Read ↗

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The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological FunctionSemantic proximity Read ↗

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