Article
No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid Hormone Parameters, Health-Related Quality of Life, and Cognitive Functioning in a Large Population-Based Cohort Study.
Thyroid : official journal of the American Thyroid Association - 1 Feb 2017
Wouters Hanneke J C M, van Loon Hannah C M, van der Klauw Melanie M, Elderson Martin F, Slagter Sandra N, Kobold Anneke Muller, Kema Ido P, Links Thera P, van Vliet-Ostaptchouk Jana V, Wolffenbuttel Bruce H R
Abstract excerpt
INTRODUCTION: The presence of the Thr92Ala polymorphism of deiodinase-2 (D2) has been thought to have several effects. It may influence its enzymatic function, is associated with increased expression of genes involved in oxidative stress in brain tissue, and may predict favorable response to combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. It was hypothesized that homozygous carriers of the...
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