Article
The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins.
Clinical endocrinology - 1 Jun 2009
van der Deure Wendy M, Hansen Pia Skov, Peeters Robin P, Uitterlinden André G, Fenger Mogens, Kyvik Kirsten Ohm, Hegedüs Laszlo, Visser Theo J
Abstract excerpt
INTRODUCTION: Genetic factors have a considerable influence on serum thyroid hormone levels. The C785T and A1814G polymorphisms, located in the 3' untranslated region of the type 1 deiodinase (D1) gene have been associated with serum FT4 and rT3 levels. OBJECTIVE: In healthy Danish twins, we examined the association of these polymorphisms with serum thyroid hormone levels and determined the proportion of genetic...
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