The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH.

doi:10.1530/EJE-11-1073

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Article

The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH.

European journal of endocrinology - 1 May 2012

Peltsverger Maya Y, Butler Peter W, Alberobello Anna Teresa, Smith Sheila, Guevara Yanina, Dubaz Ornella M, Luzon Javier A, Linderman Joyce, Celi Francesco S

Abstract excerpt

OBJECTIVE: Type 2 deiodinase gene (DIO2) polymorphisms have been associated with changes in pituitary-thyroid axis homeostasis. The -258A/G (SNP rs12885300) polymorphism has been associated with increased enzymatic activity, but data are conflicting. To characterize the effects of -258A/G polymorphism on intrathyroidal thyroxine (T(4)) to triiodothyronine (T(3)) conversion and thyroid hormone (TH) secretion...

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Identifiers

PMID: 22307573
DOI: 10.1530/EJE-11-1073
PMCID: PMC3509195

Genes

DIO2
TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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