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Collateral Damage during Dengue Virus Infection: Making Sense of DNA by cGAS

27 Apr 2017

Abstract excerpt

Early sensing of viral components or infection-induced tissue damage is a prerequisite for the successful control of pathogenic viruses by the host innate immune system. Recent results from our laboratory show how immune cells use the DNA-sensing machinery to detect intracellular damage generated early during infection by an RNA virus, namely, dengue virus (DENV). Conversely, we found that DENV can efficiently...

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PMID: 28446670
DOI: 10.1128/jvi.01081-16

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