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RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing

15 Feb 2022

Abstract excerpt

The past decade has provided critical information about the cytoplasmic innate immune sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING). These discoveries have broadened our understanding of the interconnectedness of the cGAS-STING pathway with autophagy, programmed cell death, Rig-I-like receptor (RLR) signaling, DNA independent interferon induction, and how this...

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PMID: 35180533
DOI: 10.1016/j.coviro.2022.101206

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