cGAS and STING: At the intersection of DNA and RNA virus-sensing networks

Abstract excerpt

Innate immune sensing of RNA and DNA virusesAs the first line of host defense, the innate immune system utilizes germline-encoded receptors named pattern-recognition receptors (PRRs) to detect invading pathogens.PRRs recognize conserved molecular structures of pathogens known as pathogen-associated molecular patterns (PAMPs) to initiate immune responses that counteract pathogen infection.The immunostimulatory...

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