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Mesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathway

16 Jan 2015

Abstract excerpt

Mesenchymal stem cells (MSCs) are widely used in clinical settings to treat tissue injuries and autoimmune disorders due to their multipotentiality and immunomodulation. Long-term observations reveal several complications after MSCs infusion, especially herpesviral infection. However, the mechanism of host defense against herpesviruses in MSCs remains largely unknown. Here we showed that murine...

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PMID: 25592282
DOI: 10.1038/srep07820

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