Article
Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome.
PloS one - 1 Jan 2015
Spaans Vivian M, Trietsch Marjolijn D, Peters Alexander A W, Osse Michelle, Ter Haar Natalja, Fleuren Gert J, Jordanova Ekaterina S
Abstract excerpt
INTRODUCTION: Squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (ASC) are the most common histological subtypes of cervical cancer. Differences in the somatic mutation profiles of these subtypes have been suggested. We investigated the prevalence of somatic hot-spot mutations in three well-defined cohorts of SCC, AC, and ASC and determined the additional value of mutation profiling...
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