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Article

Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2021

Selenica Pier, Alemar Barbara, Matrai Cathleen, Talia Karen L, Veras Emanuela, Hussein Yaser, Oliva Esther, Beets-Tan Regina G H, Mikami Yoshiki, McCluggage W Glenn, Kiyokawa Takako, Weigelt Britta, Park Kay J, Murali Rajmohan

Abstract excerpt

Gastric-type cervical adenocarcinoma (GCA) is an aggressive type of endocervical adenocarcinoma characterized by mucinous morphology, gastric-type mucin, lack of association with human papillomavirus (HPV) and resistance to chemo/radiotherapy. We characterized the landscape of genetic alterations in a large cohort of GCAs, and compared it with that of usual-type HPV-associated endocervical adenocarcinomas (UEAs),...

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Source

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Identifiers

PMID: 33318584
DOI: 10.1038/s41379-020-00726-1
PMCID: PMC8154628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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