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Article

Driver gene mutations in micro-invasive cervical squamous cancers have no prognostic significance.

Gynecologic oncology - 1 Apr 2022

Kashofer Karl, Regauer Sigrid, Reich Olaf, Petru Edgar, Winter Elke

Abstract excerpt

OBJECTIVE: To evaluate the prevalence of somatic gene mutations in different stages of cervical carcinogenesis placing special emphasis on micro-invasive pT1a cervical squamous cell cancers (SCC). METHODS: Micro-dissected samples of 32 micro-invasive pT1a and 55 ≥ pT1b SCC were evaluated by next generation sequencing of 50 cancer genes (cancer hot spot panel). RESULTS: At primary diagnosis, 8/32 (25%) pT1a SCC,...

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Identifiers

PMID: 35101299
DOI: 10.1016/j.ygyno.2022.01.020

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