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Article

Comprehensive Genomic Characterization of 102 Cervical Adenocarcinoma Tumors.

Medicina (Kaunas, Lithuania) - 7 Jan 2026

Toromani Gejla, Saglimbeni Grace S, Upadhyayula Bhanu Surabi, Manu Eugene, Morris Tyson J, Hsia Beau, Tauseef Abubakar

Abstract excerpt

Background and Objectives: Cervical adenocarcinoma (CAC) is a histologically distinct subtype of cervical cancer with a rising incidence in many regions. While the roles of key driver mutations are known, a comprehensive understanding of its genomic landscape, particularly variations across different populations and tumor stages, remains incomplete. This study aims to characterize the somatic genomic landscape of...

Topics

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Adenocarcinoma
Class I Phosphatidylinositol 3-Kinases
DNA-Binding Proteins
DNA Copy Number Variations
Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Protein p53

Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41597409
DOI: 10.3390/medicina62010123
PMCID: PMC12842960

Genes

TP53
KRAS
ARID1A
ATM
BCL6
ERBB2
MSH2
PIK3CA
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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